Products

Trimethoprim

Product Details

Trimethoprim is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of urinary tract infections.Target: DHFRTrimethoprim (TMP), an inhibitor of dihydrofolate reductase, decreases the level of tetrahydrofolate supplying one-carbon units for biosynthesis of nucleotides, proteins, and panthotenate. TMP caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B were most efficiently induced by TMP and coaggregated with the insoluble proteins

Density:

1.252

Boiling Point:

526 oC at 760 mmHg

Melting Point:

199-203℃

Flash Point:

271.9 oC

Storage Temperature:

2-8°C

Refractive index:

1.6000 (estimate)

Solubility:

DMSO: soluble  <0.1 g/100 mL at 24 oC

Stability:

Stable. Incompatible with strong oxidizing agents, acids.


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